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Tramadol is a highly effective non-narcotic analgesic of central action intended for oral administration in acute or chronic pain of various etiologies. Tramadol belongs to the class of moderately toxic agents and has good tolerability.
According to the statistics of the research , it is common knowledge that Tramadol penetrates the placental barrier, so it is not recommended to use the drug during pregnancy. If there are indications for analgesic therapy with opiates during pregnancy, you should limit yourself to a single use. A small amount of Tramadol penetrates into breast milk, so do not use the drug during breastfeeding. With a single use, breast-feeding cannot be interrupted.
Tramadol being an agonist-antagonist of opiate receptors, the drug has a pronounced analgesic activity. Its effect occurs 20 minutes after administration and lasts up to 5 hours.Tramadol effectively eliminates moderate pain in the postoperative period, with injuries, biliary colic, myocardial infarction, during painful diagnostic procedures. In addition, Tramadol has an antitussive effect.
When taken in therapeutic doses, Tramadol does not cause respiratory depression and does not affect the motor function of the intestine. The drug is produced in gelatine capsules of 0.05 g. Adults and children over 14 years of age are prescribed 1 capsule with a small amount of liquid.
During treatment with Tramadol, some precautions should be taken: you should avoid driving a car and performing potentially dangerous activities that require increased attention or speed of mental and motor reactions.
In patients with impaired liver or kidney function, treatment with the drug should begin with minimal doses. Special caution when taking Tramadol should be observed when prescribing it to patients with drug and alcohol dependence.
More than 20 years of clinical experience in the use of tramadol drugs indicates that the drug meets the modern requirements and can be considered an effective and safe drug for the elimination of pain.
Tramadol is a central analgesic. It has a mixed mechanism of action. It is a non-selective agonist of the opioid mu -, delta-and kappa receptors. Other mechanisms that are involved in providing the analgesic effect of tramadol hydrochloride are the inhibition of norepinephrine reuptake in neurons and the enhancement of the serotonergic response.
Tramadol should not be used for longer than the period justified from a therapeutic point of view. In patients with moderate hepatic/renal impairment, as well as in the elderly, the doses are selected individually. In moderate hepatic insufficiency, it is recommended to reduce the dose or increase the interval between doses.
In moderate renal insufficiency, it is advisable to increase the interval between Tramadol doses. For patients with creatinine clearance <30 ml/min, the interval should be increased to 12 hours. In such cases, the maximum recommended daily dose is 200 mg.
Contradictions include hypersensitivity to the active substance or other components of the drug as well as acute alcohol intoxication, acute poisoning with sleeping pills, analgesic or psychotropic drugs; severe hepatic insufficiency, severe renal insufficiency (creatinine clearance <10 ml / min), epilepsy with frequent seizures. The period of treatment with MAO inhibitors and the next 14 days after their withdrawal. It is not used for the treatment of opioid addiction. The period of pregnancy or lactation. Children under 14 years of age.
Special care should be taken when prescribing Tramadol to patients with head injuries, increased intracranial pressure, moderate renal or hepatic impairment, patients with a tendency to seizures, as well as patients with hypersensitivity to opiates.
The risk of seizures may be higher in patients who use drugs that reduce the convulsive syndrome simultaneously with Tramadol. Patients with a history of epilepsy and a tendency to epileptic seizures can be prescribed the drug only if absolutely necessary. With caution, it is used for the treatment of patients with impaired respiratory function or in the case of simultaneous use of drugs that inhibit the activity of the central nervous system because of the risk of further respiratory depression.
Tramadol contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.
Tramadol has the ability to influence the reaction speed when driving vehicles or working with other mechanisms. When using the drug, you should refrain from driving vehicles and working with other mechanisms, which requires increased attention and rapid mental and motor reactions.
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